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William E Gooding Selected Research

Antisense DNA

10/2018Phase 1 study of EGFR-antisense DNA, cetuximab, and radiotherapy in head and neck cancer with preclinical correlatives.
3/2009Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms.
5/2002Lack of toxicity of EGFR antisense gene therapy.

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William E Gooding Research Topics

Disease

65Neoplasms (Cancer)
06/2020 - 03/2002
42Squamous Cell Carcinoma of Head and Neck
01/2022 - 03/2002
15Head and Neck Neoplasms (Head and Neck Cancer)
01/2022 - 09/2004
7Neoplasm Metastasis (Metastasis)
01/2016 - 03/2002
7Melanoma (Melanoma, Malignant)
11/2012 - 09/2007
6Lung Neoplasms (Lung Cancer)
12/2015 - 03/2002
5Carcinogenesis
01/2018 - 09/2004
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
08/2017 - 03/2005
5Adenocarcinoma
02/2013 - 01/2006
4Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2022 - 11/2009
4Sarcoma (Soft Tissue Sarcoma)
10/2016 - 10/2003
4Lymphatic Metastasis
01/2016 - 04/2006
3Esophageal Neoplasms (Esophageal Cancer)
05/2011 - 03/2002
3Pneumothorax
03/2009 - 05/2007
2Carcinoma (Carcinomatosis)
10/2016 - 11/2013
2Fatigue
01/2012 - 06/2005
2Gastroesophageal Reflux (GERD)
09/2011 - 01/2005
2Necrosis
04/2003 - 12/2002
1Dermatitis
01/2022
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2020
1Bites and Stings (Sting)
01/2018
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/2017
1Pleomorphic Adenoma
10/2016
1Mouth Neoplasms (Oral Cancer)
08/2016

Drug/Important Bio-Agent (IBA)

22ErbB Receptors (EGF Receptor)IBA
10/2018 - 08/2002
13Proteins (Proteins, Gene)FDA Link
01/2020 - 03/2002
10Cetuximab (Erbitux)FDA Link
01/2022 - 09/2006
9Biomarkers (Surrogate Marker)IBA
06/2020 - 11/2012
6DNA (Deoxyribonucleic Acid)IBA
10/2018 - 01/2005
6Erlotinib Hydrochloride (CP 358,774)FDA Link
08/2017 - 12/2006
5Messenger RNA (mRNA)IBA
01/2018 - 03/2002
5src-Family KinasesIBA
01/2017 - 08/2003
5LigandsIBA
12/2006 - 03/2002
4Monoclonal AntibodiesIBA
06/2020 - 03/2002
4OligonucleotidesIBA
02/2013 - 03/2008
4Transcription Factors (Transcription Factor)IBA
08/2012 - 10/2004
4Bombesin Receptors (Bombesin Receptor)IBA
03/2008 - 03/2002
4Antisense OligonucleotidesIBA
03/2008 - 09/2003
3Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
06/2020 - 07/2011
3Antisense DNAIBA
10/2018 - 05/2002
3CytokinesIBA
01/2018 - 12/2002
3Tyrosine (L-Tyrosine)FDA Link
08/2016 - 03/2008
3Sulindac (Copal)FDA LinkGeneric
06/2014 - 12/2006
3Biological ProductsIBA
04/2014 - 09/2006
3STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
09/2012 - 03/2008
3Transforming Growth Factor alpha (TGF-alpha)IBA
03/2008 - 09/2004
2IpilimumabIBA
01/2022 - 01/2019
2InterferonsIBA
01/2018 - 11/2012
2Nucleic AcidsIBA
01/2018 - 01/2005
2Dasatinib (BMS 354825)FDA Link
01/2017 - 01/2016
2Phosphotransferases (Kinase)IBA
10/2016 - 07/2008
2Antineoplastic Agents (Antineoplastics)IBA
04/2014 - 12/2002
2Carboplatin (JM8)FDA LinkGeneric
10/2013 - 12/2002
2tremelimumabIBA
11/2012 - 01/2012
2Peptides (Polypeptides)IBA
11/2012 - 10/2003
2Tyrosine Kinase InhibitorsIBA
11/2012 - 12/2006
2Epidermal Growth Factor (EGF)IBA
11/2012 - 09/2004
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
11/2012 - 05/2012
2AntigensIBA
05/2012 - 03/2005
2Gefitinib (Iressa)FDA Link
07/2011 - 07/2008
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2011 - 02/2005
2Interleukin-2 (IL2)IBA
10/2008 - 09/2007
2Docetaxel (Taxotere)FDA Link
03/2008 - 10/2003
2Cisplatin (Platino)FDA LinkGeneric
09/2006 - 10/2004
2Interferon Regulatory Factor-1 (Interferon Regulatory Factor 1)IBA
01/2006 - 11/2004
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2005 - 08/2002
2Cyclin D1IBA
02/2005 - 08/2002
1SteroidsIBA
01/2022
1ficlatuzumabIBA
06/2020
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2019
1rilotumumabIBA
08/2017
1TOR Serine-Threonine KinasesIBA
12/2016
1EverolimusFDA Link
12/2016
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
10/2016
1Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA
10/2016
1Phosphatidylinositol 4,5-Diphosphate (Phosphatidylinositol 4,5 Diphosphate)IBA
10/2016
1CarcinogensIBA
08/2016
1statticIBA
08/2016
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
08/2016
1Discoidin Domain Receptor 2IBA
01/2016
1NucleotidesIBA
01/2016
1Caspase 8 (Caspase-8)IBA
01/2016
1Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)IBA
01/2016

Therapy/Procedure

17Therapeutics
01/2019 - 09/2002
8Radiotherapy
01/2022 - 01/2003
5Immunotherapy
11/2017 - 10/2008
4Radiofrequency Ablation
11/2009 - 04/2003
4Catheters
03/2009 - 04/2003
3Drug Therapy (Chemotherapy)
10/2008 - 06/2005
2Injections
10/2018 - 11/2004
2Free Tissue Flaps
01/2017 - 12/2014
2Aftercare (After-Treatment)
01/2017 - 12/2015
2Chemoprevention
08/2016 - 02/2011
2Length of Stay
12/2014 - 03/2011
2Esophagectomy
02/2013 - 04/2009
2Neoadjuvant Therapy
11/2012 - 05/2011
2Neck Dissection (Radical Neck Dissection)
02/2011 - 11/2009
2Brachytherapy
11/2009 - 09/2006
1Organ Transplantation
09/2017
1Precision Medicine
01/2016